Mucoepidermoid carcinoma of the bronchus in a 4-year-old child. A high-grade variant with lymph node metastasis

Primary pulmonary high-grade mucoepidermoid carcinoma (MEC) with a cystic airspace is uncommon, and early metastasis is extremely rare. In such cases, however, it is clinically important for clinicians to consider whether the tumor has spread to the lymph nodes through the cystic airspace. A 77-year-old man presented to our hospital with cough and hemoptysis. Chest computed tomography showed a 25-mm-diameter mass with a cystic airspace located in the upper lobe of the left lung. The possibility of malignancy was considered. Without a definitive preoperative diagnosis, left upper lobectomy and mediastinal lymphadenectomy were performed. Histopathological examination revealed the typical histological characteristics of high-grade MEC (stage IA) and no lymph node metastasis. However, lymph node metastasis was found 6 months after surgical resection, and radiochemotherapy was performed. The patient developed widespread metastatic disease 4 months following completion of radiochemotherapy and died 2 months later. Primary pulmonary MEC with a cystic airspace is a rare malignant disease with uncommon imaging findings. Complete surgical resection is the main treatment method for high-grade MEC. In this case, we hypothesize that early metastasis was caused by seeding of tumor cells through the cystic airspace.

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Deep Parotid Lymph Node Metastasis Is Associated With Recurrence in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2019.01.031 ◽

2019 ◽

Vol 77 (7) ◽

pp. 1505-1509 ◽

Cited By ~ 2

Author(s):

Xue Shang ◽

Qigen Fang ◽

Fei Liu ◽

Junfu Wu ◽

Ruihua Luo ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Parotid Gland ◽

Mucoepidermoid Carcinoma ◽

High Grade ◽

Node Metastasis

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Tumour-Infiltrating Lymphocytes (TILs) and PD-L1 Expression Correlate with Lymph Node Metastasis, High-Grade Transformation and Shorter Metastasis-Free Survival in Patients with Acinic Cell Carcinoma (AciCC) of the Salivary Glands

Cancers ◽

10.3390/cancers13050965 ◽

2021 ◽

Vol 13 (5) ◽

pp. 965

Author(s):

Selina Hiss ◽

Markus Eckstein ◽

Patricia Segschneider ◽

Konstantinos Mantsopoulos ◽

Heinrich Iro ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Node Metastases ◽

Immune Cell ◽

High Grade ◽

Free Survival ◽

Node Metastasis ◽

Node Metastases ◽

High Grade Transformation ◽

Infiltrating Lymphocytes

Objectives: The aim of this study was to assess the number of tumour-infiltrating lymphocytes (TILs) and the expression of Programmed Cell Death 1 Ligand 1 (PD-L1) in Acinic Cell Carcinoma (AciCC) of the salivary glands, to enable a correlation with clinico-pathological features and to analyse their prognostic impact. Methods: This single centre retrospective study represents a cohort of 36 primary AciCCs with long-term clinical follow-up. Immunohistochemically defined immune cell subtypes, i.e., those expressing T-cell markers (CD3, CD4 and CD8) or a B-cell marker (CD20) were characterized on tumour tissue sections. The number of TILs was quantitatively evaluated using software for digital bioimage analysis (QuPath). PD-L1 expression on the tumour cells and on immune cells was assessed immunohistochemically employing established scoring criteria: tumour proportion score (TPS), Ventana immune cell score (IC-Score) and combined positive score (CPS). Results: Higher numbers of tumour-infiltrating T- and B- lymphocytes were significantly associated with high-grade transformation. Furthermore, higher counts of T-lymphocytes correlated with node-positive disease. There was a significant correlation between higher levels of PD-L1 expression and lymph node metastases as well as the occurrence of high-grade transformation. Moreover, PD-L1 CPS was associated with poor prognosis regarding metastasis-free survival (p = 0.049). Conclusions: The current study is the first to demonstrate an association between PD-L1 expression and lymph node metastases as well as grading in AciCCs. In conclusion, increased immune cell infiltration of T and B cells as well as higher levels of PD-L1 expression in AciCC in association with high-grade transformation, lymph node metastasis and unfavourable prognosis suggests a relevant interaction between tumour cells and immune cell infiltrates in a subset of AciCCs, and might represent a rationale for immune checkpoint inhibition.

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Prognostic significance of lymph node metastasis and bone, major vessel, or nerve involvement in adults with high-grade soft tissue sarcomas

Cancer ◽

10.1002/1097-0142(19880901)62:5<999::aid-cncr2820620527>3.0.co;2-n ◽

1988 ◽

Vol 62 (5) ◽

pp. 999-1006 ◽

Cited By ~ 37

Author(s):

Wlodzimierz Ruka ◽

Lawrence J. Emrich ◽

Deborah L. Driscoll ◽

Constantine P. Karakousis

Keyword(s):

Lymph Node ◽

Soft Tissue ◽

Lymph Node Metastasis ◽

Prognostic Significance ◽

Soft Tissue Sarcomas ◽

High Grade ◽

Node Metastasis ◽

Nerve Involvement ◽

Major Vessel

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High-grade Papillary Early Gastric Carcinoma With High Risk for Lymph Node Metastasis and Poor Prognosis

The American Journal of Surgical Pathology ◽

10.1097/pas.0000000000001759 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Yuqing Cheng ◽

Mingzhan Du ◽

Xiaoli Zhou ◽

Lingchuan Guo ◽

Kequn Xu ◽

...

Keyword(s):

Lymph Node ◽

High Risk ◽

Lymph Node Metastasis ◽

Gastric Carcinoma ◽

Poor Prognosis ◽

Early Gastric Carcinoma ◽

High Grade ◽

Node Metastasis

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ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-11-2449 ◽

2012 ◽

Vol 18 (15) ◽

pp. 4163-4172 ◽

Cited By ~ 29

Author(s):

Xin Gao ◽

Liao-Yuan Li ◽

Fang-Jian Zhou ◽

Ke-Ji Xie ◽

Chun-Kui Shao ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Cancer Diagnosis ◽

Intraepithelial Neoplasia ◽

Prostatic Intraepithelial Neoplasia ◽

High Grade ◽

Node Metastasis ◽

Erg Rearrangement ◽

Subsequent Cancer

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Effects of Concentrated Growth Factor and Cervical Lymph Node Metastasis on the Prognosis of Mucoepidermoid Carcinoma of the Parotid Gland

Nepalese Journal of Cancer ◽

10.3126/njc.v4i1.31775 ◽

2020 ◽

Vol 4 (1) ◽

pp. 45-50

Author(s):

Shang-Zhi Han ◽

Xin Lv ◽

Xi-Bo Chen ◽

Ying-Ying Xu ◽

Rui Liu ◽

...

Keyword(s):

Lymph Node ◽

Survival Rate ◽

Lymph Node Metastasis ◽

Parotid Gland ◽

Distant Metastasis ◽

Mucoepidermoid Carcinoma ◽

Cervical Lymph Node Metastasis ◽

Pathological Grade ◽

Node Metastasis ◽

Independent Risk Factors

Introduction: Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy. As studies reported on large cases of mucoepidermoid carcinoma of the parotid glands are few, this paper aims to research the effects of clinical and pathological factors, such as applying concentrated growth factor (CGF) on repairing and cervical lymph node metastasis, on the prognosis of mucoepidermoid carcinoma of the parotid gland. Methods: The retrospective analysis of prognostic factors was conducted based on 176 cases with mucoepidermoidcarcinoma of the parotid gland, who received treatment at the Affiliated Hospital of Chengde Medical College during the period of March 2000 to March 2012. Results: The Five-year overall survival rate was 75.57%, while the Five-year tumor-free survival rate was 64.77%. Univariate analysis showed that the influential factors for the prognosis of mucoepidermoid carcinoma of the parotid gland included surgical approach, tumor size, clinical stage, pathological grade, lymph node metastasis, and distant metastasis, etc; among which pathological grade, lymph node metastasis, and distant metastasis were indicated by multivariate analysis to be the independent risk factors. Conclusion: The survival rate of mucoepidermoid carcinoma of the parotid gland is relatively high. Lymph node metastasis, pathological grade, and distant metastasis are the independent risk factors that affect the prognosis of patients with mucous epidermis carcinoma of the parotid gland.

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